The anti-SARS-CoV-2 IgG antibody (often called a serology) test is designed to determine how much antibodies the body has produced after a COVID-19 infection, whether a person has previously been infected with the virus that causes COVID-19, and how much antibodies the body has produced against the virus after a vaccine against COVID-19. Thus, the test shows whether the body has formed an immune response against the COVID-19 infection.
When does the body start producing antibodies?
Anti-SARS-CoV-2 IgG antibodies begin to be produced approximately 4-7 days after the onset of symptoms and can be detected and measured in the blood approximately 7-10 days after the onset of symptoms. How is the investigation conducted? The anti-SARS-CoV-2 IgG antibody test is performed by taking the patient’s capillary or venous blood (serum, plasma EDTA). What do the results of the study show? A positive result indicates that Anti-SARS-CoV-2 IgG antibodies are detected and the person:
• sick for more than 10 days with a COVID-19 infection or
• is already sick with a COVID-19 infection, has developed immunity. A negative result indicates that Anti-SARS-CoV-2 IgG antibodies are not detected and the person:
• did not suffer from a COVID-19 infection;
• has a COVID-19 infection, but the blood sample was taken too early, i.e. there are not enough antibodies yet.
Who is recommended for testing?
• For patients traveling abroad who need a document about the immunity against the SARS-CoV-2 virus. After this examination, a certificate of examination can be issued.
• For patients who want to know if they have been in contact with the SARS-CoV-2 virus.
• For patients who want to know whether they have developed immunity against the SARS-CoV-2 virus and to determine the antibody titer.
• Evaluating the amount of antibodies in the donor plasma of patients who have recovered from COVID-19.
• Determining the immune status prior to vaccination to vaccinate seronegative individuals.
• Evaluating vaccine-induced immune responses after vaccination.
Antibodies against the spike protein of SARS-CoV-2, which determine the body’s response to infection, are being tested.
What is important to know?
It is not yet fully known how long anti-SARS-CoV-2 IgG antibodies remain in the body and what is the sufficient amount of anti-SARS-CoV-2 IgG antibodies to ensure immunity against the SARS-CoV-2 coronavirus. Anti-SARS-CoV-2 antibodies may often not be found (negative) in the asymptomatic form of COVID-19. Anti-SARS-CoV-2 antibody tests do not show whether a person carries the virus and can infect others.
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